Naked mole rat may hold the secret to long life

ScienceDaily (July 2, 2012) ? Compared to the average three year life span of a common rat, the 10 to 30 year life of the naked mole rat, a subterranean rodent native to East Africa, is impressive. And compared to the human body, the body of this rodent shows little decline due to aging, maintaining high activity, bone health, reproductive capacity, and cognitive ability throughout its lifetime. Now a collaborative of researchers in Israel and the United States is working to uncover the secret to the small mammal's long -- and active -- lifespan.

Dr. Dorothee Huchon of Tel Aviv University's Department of Zoology, Prof. Rochelle Buffenstein of the University of Texas Health Science Center in San Antonio, and Dr. Yael Edrey of the City College of New York are working together to determine whether the naked mole rat's unusually high levels of NRG-1, a neuroprotecting protein, is behind the naked mole rat's three-decade life span. Because rodents have an 85 percent genetic similarity to humans, it may hold the key to a longer and healthier life for us as well.

This research has been published in the journal Aging Cell.

A family trait?

Genetic analysis comparing the mole rat with several other rodent species revealed that high levels NRG-1 in adults correlated with a longer life span. Of all the species the researchers studied, the naked mole rat had the most plentiful and long-lasting supply of the protein, maintaining a consistent level throughout its lifetime. It is concentrated in the cerebellum, the part of the brain important to motor control.

Dr. Huchon, an evolutionary biologist, joined the project to lend her expertise on rodent genetics. She studied seven species of rodents, including guinea pigs, mice, and mole rats, to determine the genetic relationships between them. Her analysis revealed that the correlation between life span and NRG-1 levels was independent of evolutionary lineage -- meaning that it was unique to the naked mole rat, not a common trait of these rodent species.

Prof. Buffenstein and Edrey monitored NRG-1 levels in a population of naked mole rats ranging in age from one day to 26 years. They found that throughout their lives, levels of NRG-1, essential for normal brain functioning, were sustained. The protein is a neuroprotector, safeguarding the integrity of neurons, which may explain why naked mole rats are able to live so healthfully for such a long period of time.

Shaping future aging research

This discovery is an important first step towards understanding how aging -- and the NRG-1 protein in particular -- functions in these interesting animals, says Dr. Huchon. Future research could reveal how NRG-1 helps to maintain neuron integrity and lead to discoveries about human aging as well.

The naked mole rat, a burrowing rodent that lives in colonies much like those of ants, has already proven to be an excellent tool for aging and biomedical research because it is resistant to cancer and maintains protein integrity in the brain despite being exposed to oxidative damage, Dr. Huchon says.

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The above story is reprinted from materials provided by American Friends of Tel Aviv University.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Yael H. Edrey, Diana Casper, Dorothee Huchon, James Mele, Jonathan A. Gelfond, Deborah M. Kristan, Eviatar Nevo, Rochelle Buffenstein. Sustained high levels of neuregulin-1 in the longest-lived rodents; a key determinant of rodent longevity. Aging Cell, 2012; 11 (2): 213 DOI: 10.1111/j.1474-9726.2011.00772.x

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://www.sciencedaily.com/releases/2012/07/120702162327.htm

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Party's checkered past challenges Mexico's president-elect

The 45-year-old former governor of the state of Mexico and husband of a soap opera star is earning rock-star levels of attention, despite concerns that he is affiliated with a political party voted out over a decade ago amid allegations of corruption. NBC's Mark Potter reports.

By msnbc.com news services

The apparent winner of Mexico's presidential race, Enrique Pena Nieto, struggled Monday with the sticky bonds of his party's notorious past, the limitation of his mandate and an opponent who has yet to concede defeat.?

His long-ruling and now-returned Institutional Revolutionary Party, the PRI, won only about 38 percent of the vote and is unlikely to get a majority in Congress. In fact, it may lose seats.


He faces an old guard in the PRI that still exercises considerable power, an ongoing war against fierce drug cartels and a still sluggish economy. His closest rival, leftist Andres Manuel Lopez Obrador, who polled a higher-than-expected vote of about 32 percent, has refused to accept the loss, and many of his militant followers are suspicious of the results.

President Barack Obama called Pena Nieto on Monday to congratulate him. The U.S. Embassy in Mexico City said Obama told him the United States "looks forward to advancing common goals, including promoting democracy, economic prosperity, and security in the region and around the globe, in the coming years."

Mexico's old rulers claim presidential triumph

Pena Nieto's account of the talk suggested his party has left behind the touchy nationalism of the past. He expressed interest in cooperation in security, commerce and infrastructure, but didn't bring up the traditional Mexican issue of U.S. immigration reform to help the 12 million Mexicans who live in the United States.

'Productive integration of North America'
Pena Nieto said he wanted "a relationship that will allow the productive integration of North America."

In Sunday's elections, Mexicans voted above all for a known quantity, the camera-friendly candidate of the party that ruled Mexico without interruption from 1929 to 2000.

But the PRI returns to power in unknown political terrain, where Mexico is more divided, more violent and less tightly controlled, raising the potential for political disputes on top of the drug war. The battle against drug cartels has already cost more than 47,500 lives and may have contributed to the decline of President Felipe Calderon's conservative National Action Party, whose candidate dropped to third place with about 25 percent of the preliminary vote count.

Pena Nieto pledged to continue that anti-drug offensive, but "with a new strategy to reduce violence and protect, above all, the lives of Mexicans." He promised there would be "no pact or truce" with drug cartels, but clearly some supporters expected the PRI to establish some sort of modus vivendi with the gangs, something party leaders were accused of doing in the past.

"He'll stabilize the cartels. He'll negotiate so they don't hurt innocents," Martha Trejo, 37, a PRI supporter from the Gulf coast city of Tampico, said at Sunday's victory rally.

Pena Nieto said Monday he will favor "well-aimed, precision strikes" against the cartels, and more cooperation with U.S. authorities, something that Calderon has already developed far beyond his predecessors.

Hope for new faces
The biggest immediate task facing Pena Nieto is to convince the 62 percent of voters who didn't vote for him that he is not planning a return to the corrupt, authoritarian and free-spending ways of the PRI of the past. Even some of Pena Nieto's supporters, such as school teacher Maria Santillan, 51, expressed hope he would surround himself "with new faces, people who aren't so corrupted."

All the potential conflicts were apparent at the victory rally just after midnight at the PRI's cavernous compound in Mexico City, where Pena Nieto was surrounded by graying holdovers from the PRI's glory days and a raucous crowd of supporters expecting jobs, hand-out programs and a quick reduction in drug violence.

"The PRI have learned to listen to the people, they have learned they are not kings ... to engage with people, understand them, and rule in a coalition with the people," said 20-year-old student Hector Perez.

"There is no return to the past," Pena Nieto said. "I am going to be a democratic president, who understands the changes the country has undergone in recent decades," he said in an apparent reference to reforms that created a more-level political playing field with energized civic organizations putting pressure on governments.

Pena Nieto promised a government "of national unity," but hasn't yet named any Cabinet choices, though he has said?his campaign chief, Luis Videgaray, 43, would form part of his government team. Videgaray is well regarded by investors and seen as a possible choice for finance minister.

Nieto also suggested he would seek further internal reforms of his party, which for most of its history followed presidential dictates unquestioningly and rigged votes if it could not win elections that were already tilted sharply in its favor. The party liberalized in its final two decades, but it remained steadfast in protecting its leaders and stonewalling on probes of corruption.

Calderon was quick to recognize the PRI victory, and his party may serve as an ally in Congress in voting through some measures, such as Pena Nieto's call to open the state-owned oil sector to private investment. Pena Nieto told reporters Monday he would start working immediately on tax, energy and labor reforms, and would "sit down with the president (Calderon) ... to talk about what can be put forward before I take office" on Dec. 1.

But those very proposals, especially on the oil industry, have drawn the leftist Democratic Revolution Party, the PRD, into the streets for angry protests in the past.

Rival won't concede
PRD candidate Lopez Obrador has not conceded Sunday's elections, telling his supporters late Sunday, "You know these elections were not equitable," a reference to his allegations that Pena Nieto exceeded campaign spending limits and benefited from favorable coverage in Mexico's semi-monopolized television industry. Lopez Obrador has not said if he will challenge Sunday's vote results, but he led nearly two months of street blockades in Mexico City in 2006 to protest a narrow loss he attributed to fraud.

"We have information that indicates something different from what they're saying officially," Lopez Obrador said of the vote results, but added "We're not going to act in an irresponsible manner."

Lopez Obrador's party actually did better than pre-election polls had projected, winning apparent victories in three of the seven state elections on Sunday. The PRD was on track to win an overwhelming victory in Mexico City, the nation's capital and largest city, as well as taking the governorships of Morelos state to the south and the Gulf coast state of Tabasco, both of which were held by other parties. The PRI seemed to have taken the governorship of the western state of Jalisco from National Action.

Despite winning the presidency, the PRI may actually lose seats in Congress. The PRI-led coalition with the Green Party had about 38 percent of the congressional vote, with 95 percent of ballots counted on Monday. The coalition won about 46 percent in the last legislative vote three years ago.

Many Mexicans questioned why most pre-election polls underestimated support for Lopez Obrador by five or six percentage points, well outside those polls' margin of error. Lopez Obrador had claimed the polls were being manipulated, an accusation that accompanied frequent complaints that Pena Nieto was running a far more expensive campaign than his rivals.

Jorge Buendia of the polling firm Buendia and Laredo said some people who said they would vote for Pena Nieto appear to have changed their minds. There was also a surge in support for Lopez Obrador in the final days that couldn't be fully measured because electoral law effectively prohibits polling in the last week before the elections.

The PRI's victory appeared to be, above all, a triumph of pragmatism and power-broker politics. Few of those at his victory rally Sunday expressed the high-flown rhetoric about democratic transition and reform that were popular when National Action won the 2000 and 2006 elections. For its decades in power, the party excelled at handing out patronage jobs as well as work and business permits in exchange for votes.

Jaime Bernal, 48, who works as an aide to a PRI congressman, said at the rally the secret to the party's comeback was recognizing "the important thing for people is that they have something to eat, a job to support themselves."

But he also praised Pena Nieto's ease at working crowds, shaking hands and hugging people, a talent the party had lost during two decades of PRI presidents known as market-oriented "technocrats."

The Associated Press and Reuters contributed to this report.

More world news from msnbc.com and NBC News:

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Source: http://worldnews.msnbc.msn.com/_news/2012/07/02/12528602-partys-notorious-past-weak-mandate-challenge-mexicos-president-elect?lite

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BBC introduces Red Button to the internet, thinks they'll be great pals

BBC to introduce Red Button to the internet, thinks they'll be great pals

Since 1999, the BBC's Red Button feature has delivered alternative camera angles, sports scores and the like over broadcast spectrum, but it's now set to become internet enabled. Channel surfers shouldn't expect a full-blown web experience, however, as the Beebs stresses it's not about to include everything and the kitchen sink in terms of functionality. Rather, their Connected Red Button aims for simplicity. Punching the clicker could bring up the iPlayer to catch previous episodes of shows or save recipes from a cooking program for later viewing on a computer or smartphone. Companion screen experiences such as the Antiques Roadshow app, which is slated for a September release, are also part of their web-connected roadmap. Mum's the word on when these new features might roll out, but we're promised the BBC's Olympics coverage will give us a taste of what's to come.

BBC introduces Red Button to the internet, thinks they'll be great pals originally appeared on Engadget on Sat, 30 Jun 2012 11:46:00 EDT. Please see our terms for use of feeds.

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Mexico poised to return old ruling party to power

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Source: http://news.yahoo.com/mexico-could-return-old-ruling-party-power-054023267.html

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LG Optimus L7 review: a beautiful, entry-level Android 4.0 smartphone with LG's new UI 3.0

Consider your last trip to the car dealership. Let's say you saved up and hit up BMW. While you might've looked at -- or even test driven -- the M3, there's a good chance that your better judgment (and your budget) led you to drive off of the lot with a 328i. Sure, it's only got a four-cylinder engine inside, but the car offers great handling and good gas mileage. Better yet, you didn't have to spend an atrocious amount of money to get behind the wheel. The same goes with mobile phones. While it's fun to dream of owning a One X, a Galaxy S III or an Optimus 4X HD, they're called superphones for a reason: they cater to power-hungry individuals with a fair amount of disposable income. Like supercars, they're designed to bring people into the store, even if shoppers ultimately leave with something else in hand.
More Info
Enter the LG Optimus L7. Positioned at the higher end of the company's entry-level lineup, it aims to be the 328i of smartphones. Sure, no one's lining up to drool over it, but LG is aiming for this to be a practical choice with just enough elegance and pizzaz to keep consumers grinning. Of course, that sweet spot is difficult to achieve, and we've seen plenty of smartphone manufacturers miss the mark in attempting to balance performance and amenities with a palatable price. So, does the Optimus L7 rise to the challenge? We've spent the past week with it as our daily driver, and we're ready to make the call. Read on for the answer.Gallery: LG Optimus L7 review

Continue reading LG Optimus L7 review: a beautiful, entry-level Android 4.0 smartphone with LG's new UI 3.0
LG Optimus L7 review: a beautiful, entry-level Android 4.0 smartphone with LG's new UI 3.0 originally appeared on Engadget on Fri, 29 Jun 2012 16:15:00 EDT. Please see our terms for use of feeds.

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Best Internet Marketing Strategies For Small Business In 2012 ...

Filed under the topic: ideas

?????? Best Internet Marketing Strategies in 2012 Best Internet Marketing Strategies in 2012

New York, NY ? Internet marketing tips blog, WebTrafficToolkit.com, has just published their 3 best internet marketing strategies for small businesses in 2012.

These best internet marketing strategies are part of the $1K A Day In 60 Days Marketing Plan that thousands of online entrepreneurs and offline small business owners are currently tapping into at http://webtraffictoolkit.com/onlinebiz.html

*?Viral PDF?Internet Marketing?- ?Viral PDF marketing involves writing a high quality short report or ebook and then syndicating it to numerous online sources. This can include document sharing sites such as scribd, docstoc and slideshare.net.?

* Small Business Blogging ? ?Write a daily blog post for your small business blog. This does not need to be anything complicated. Just a simple 500 word article around a relevant keyword that your potential customers will be searching for online. The more content you have out there the more website traffic you will get.?

* SEO Online Press Releases ? A regular press release is an excellent idea for the ongoing internet marketing strategy for any small business owner. Try to tie in your press releases with current news trends for maximum exposure. PRWeb and PRNewswire are excellent online press release distribution sites for this.?

Readers are encouraged to check out the $1K A Day In 60 Days System that makes use of these strategies at http://webtraffictoolkit.com/onlinebiz.html

About WebTrafficToolkit.com:

WebTrafficToolkit.com is an internet marketing strategies?website that teaches small business owners how to leverage the power of the internet for more traffic, leads, and sales.

Related articles:

Best Social Networking Marketing Strategies in 2012 Revealed by Web Marketing Blog3 Online Marketing Tips For Small Businesses Revealed By WebTrafficToolkit.comViral Video Marketing Tips To Help YouTube Videos Go Viral Just Published By Business Marketing BlogTwitter Marketing and Facebook PPC Are Among Top 3 Social Media Marketing Strategies In 2012Content Marketing Strategy For Small Businesses In 2012 Just Published Posted by Adam on Jun 27 2012. All trademarks acknowledged. Filed under Press Release. Comments and Trackbacks are open. Follow responses: RSS 2.0

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Relative Terms: Businessb | httpsmallbusiness-howtoadvicetips-combest-internet-marketing-strategies-for-small-business-in-2012utm_sourcerss | bMarketingb | bSmall | internet-marketing | internet | Strategies

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Source: http://smallbusiness.howtoadvicetips.com/best-internet-marketing-strategies-for-small-business-in-2012/?utm_source=rss&utm_medium=rss&utm_campaign=best-internet-marketing-strategies-for-small-business-in-2012

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Why small businesses should scrap strategic planning

Most of what we learn in business schools and textbooks is written for large companies. We make the erroneous assumption that since every small company wants to grow but it doesn?t.

What fast-growing companies need is strategic thinking, not strategic planning, the practice of hitting every challenge and opportunity strategically.

Three things you can do to turn your size into an advantage?

Source: http://www.crmstrategy.com.au/why-small-businesses-should-scrap-strategic-planning/

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Amarielle Plays! Tribes:Ascend??Badly

Posted by By Amarielle at 29 June, at 20 : 45 PM Print

Another day, another game Amarielle can?t play very well. This time it is Tribes:Ascend, a free to play FPS game. Want to play? Join with my referral link: account.hirezstudios.com Or if you prefer, here is the direct site link: account.hirezstudios.com If you want 250 gold free, simply head to the Tribes:Ascend Facebook: www.facebook.com Website & Forums: www.amarielle.eu Facebook: www.facebook.com/AmarielleEU Twitter: www.twitter.com/AmarielleEU Game Servers: www.amarielle.eu/servers Donate: www.amarielle.eu/donate

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Source: http://www.amarielle.eu/amarielle-plays-tribesascend-badly/

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Upset in 200 breast: Weltz beats Hansen, Shanteau

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Source: http://news.yahoo.com/upset-200-breast-weltz-beats-hansen-shanteau-002002047--oly.html

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