OWC offers 480GB SSD upgrade for Retina MacBook Pro, requires screwdriver and careful math

OWC offers 480GB SSD upgrade for Retina Macbook Pro, requires screwdriver and careful math

Order up a Retina MacBook Pro and you'll likely be confronted with a gravelly message about how the SSD is "built into the computer" and not user-upgradeable. As it turns out, that's not quite true -- so long as you're prepared to ignore a whole bunch of other warnings written inside the chassis itself, iFixit has shown how to remove the factory drive and now OWC has a new SSD to replace it with. The only downside is the cost: at $580, OWC's 480GB Mercury Aura Pro is actually more expensive than Apple's official 512GB upgrade. In an effort to sweeten the deal, OWC is offering those who buy before September 30th a compact USB 3.0 enclosure to make use of the freed-up drive. Alternatively, you may want to wait for prices to drop or for OWC to offer an even bigger capacity with better cost / benefits.

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ExxonMobil begins probing Arctic with Rosneft

Russia's main oil producer Rosneft said on Thursday it had joined forces with ExxonMobil and begun exploring the Arctic for the vast energy resources believed to be hidden under its forbidding seas.

The landmark announcement comes one year ahead of schedule and almost exactly 12 months after the US super-major squeezed out the British energy group BP to claim a coveted spot as Rosneft's Arctic oil development partner.

A Rosneft official said an ExxonMobil seismic survey vessel called the Western Trident and two of the state firm's Russian ships had anchored in the Kara Sea off Siberia to begin probing its deep sands.

"The work programme has been developed jointly with ExxonMobil," the Russian firm added in a statement.

Rosneft said the exploration covers thousands of square kilometres (miles) in the first two of the three Arctic blocks included in a $3.2 billion deal that also covers parts of the Black Sea.

Neither company expects to begin producing commercial-grade oil in the region until early next decade.

But both hope that being the first through the door to the frozen territory will allow them to become long-term global leaders by managing to secure vast future sources of explorable energy ahead of their rivals.

Rosneft has since also arranged similar tie-ups with Italy's ENI and Norway's Statoil -- deals marking Russia's first concerted attempt to drill seemingly-inaccessible fields for which it previously lacked the technology.

All three strategic partnerships see Western majors share their know-how and fund most of the initial project work on sectors owned by Rosneft under licence from the Russian state.

Russia's oil production rates are in fact slowly declining because of the gradual depletion of easier-to-access fields that were first discovered by the Soviets nearly half a century ago.

Yet Middle East turmoil has long made Russia into a tempting target for world majors with experience in digging for oil in politically challenging environments.

ExxonMobil was one of the first Western majors to break into the post-Soviet energy market and is currently also developing oil and gas off Sakhalin Island in the Pacific.

Rosneft's current chief executive Igor Sechin said on a swing through New York in April that he viewed the ExxonMobil agreement was "a long-term collaboration that would be extended for decades -- 30, 40 or 50 years."

The mutual benefits of joint exploration have escaped Russia for much of the past two decades as the Kremlin continued to closely guard access to its natural resources.

But President Vladimir Putin -- his first two Kremlin terms punctuated by a strong state ownership campaign -- has vowed to open up the Arctic to private players under tight rules that still would only give them minority stakes.

The decision also allows Rosneft to finally expand its production base outside Russia and gain access to projects such as the deep-water one ExxonMobil is operating in the Gulf of Mexico.

The ExxonMobil agreement also allows Rosneft to try and develop light crude from the so-called "tight oil" fields it owns but had lacked the expertise to profit from in West Siberia.

The first drilling for geological studies in that region is scheduled to begin next year.

Source: http://news.yahoo.com/exxonmobil-begins-probing-arctic-rosneft-000057050.html

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Healthful Foods Give You All-Over Beauty You Can Count On ...

If you want to add a pinch of color to your face midday, consider stocking up on a stick of cream blush or a gel-based cheek blusher. Apply a small amount to the apples of your cheek, then blending in circular motions. This keeps your face looking fresh in a natural and easily applied in a manner that is especially flattering.

Drink enough water. Every cell in your body needs water to function; in fact, the human body is 60 to 70% water. If you aren?t drinking your eight to ten glasses of clean water daily, you are putting yourself at risk for dry, flaky skin as well as lifeless hair and brittle nails. Drink up and look your best.

To get even more mileage out of your favorite eye gel, keep it in the refrigerator! The ingredients in eye gel work hard to restore and protect the delicate skin around your eyes and keeping it cold enhances the refreshment factor ten fold! The cold will also work immediately to reduce that dreadful puffiness!

Blot oily skin. If you are out on the town and notice your face is oily, use toilet paper to blot your skin. This works as well as any blotting paper and will remove any excess oil you may have on your skin and give you a perfect flawless look.

If you have large ears and you want to hide them, you may want to consider growing your hair long enough so that you can cover them. Try to avoid putting your hair in a bun or ponytail as these hair styles will just make your large ears more noticeable.

The main factors to pay attention to when you are trying to work on your appearance or that of someone near you is fitness, clothes, skin care and general posture. By working on each of these main topics, you will be able to build a better and more beautiful version of yourself.

If you have overly round eyes, you can elongate them by adjusting your eyeliner application. The outer two-thirds of your lower and upper lash lines should be lined with a dark brown liner. The two lines should meet at the outer corner of each eye. Finally, apply two coats of mascara to your outer upper lashes.

Most women would be surprised to know that the average female devotes more than 60 hours of her life to the ordeal of shaving and waxing. Laser hair removal, while somewhat costly, will save you a great deal of time and nicks on your fire red 4s and jordan retro 4 2012, underarm, face, and bikini area.

Beauty is important to many people, and can be a great source for high self-esteem. While appearance is only one part of beauty, doing whatever makes you feel you look your best is a big step in the right direction. Remember the tips in this article to start showing your inner beauty!

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'CYCLOPS' genes may serve as an Achilles' heel in tumor cells

ScienceDaily (Aug. 15, 2012) ? The genomic tumult within tumor cells has provided scientists at Dana-Farber Cancer Institute and the Broad Institute of MIT and Harvard with clues to an entirely new class of genes that may serve as an Achilles' heel for many forms of cancer.

As reported in the Aug. 17 issue of the journal Cell, the researchers identified 56 such genes, only a few of which had previously been identified as potential targets for cancer therapy. Unlike most such targets, these genes don't cause normal cells to turn cancerous. Instead, they are essential to all cells but have been disrupted as cancer progresses.

"One of the hallmarks of cancer is genomic instability, in which entire sections of chromosomes can be lost or duplicated many times over," says Dana-Farber's Rameen Beroukhim, MD, PhD, who co-led the study. "The result is that genes residing in those areas are either deleted or significantly over-copied."

This roiling of the chromosomes often leads to partial loss of essential genes, leaving cancer cells with barely enough of these genes to survive. Such genes become lifelines for tumor cells. Blocking them with drug molecules is far more likely to harm cancer cells than normal cells.

One way that cancers lose these essential genes is by the loss of nearby tumor suppressor genes, which act as a brake against runaway cell growth. Whereas normal cells harbor two copies of each gene, cancers often lose at least one copy of important tumor suppressor genes, unleashing cell proliferation.

"When tumor suppressor genes are lost, it's common for several nearby genes -- which play no role in cancer development -- to be lost as well," explains the study's co-senior author William Hahn, MD, PhD, of Dana-Farber. Nearly 20 years ago, a scientist published a theory that blocking the remaining copies of these neighboring genes would cripple cancer cells' ability to grow and divide.

The author of that paper, in 1993, was Emil "Tom" Frei III, MD, who was Dana-Farber's director and physician-in-chief from 1972-1991. At the time, the tools didn't exist to determine whether the theory was valid. Only now, with the development of cutting-edge genomic technology, were researchers able to put it to the test.

Investigators began by scanning more than 3,100 samples of different types of cancers, and found that most were missing copies of genes across wide stretches of the genome. They then analyzed data from Project Achilles, a Dana-Farber research effort that has uncovered hundreds of genes critical to the reproduction of cancer cells.

Researchers combined both sets of data to find instances where the loss of one copy of a gene rendered the remaining copy especially important to the cancer cell. From an initial pool of 5,312 genes, researchers identified 56 that met the desired criteria. They dubbed them CYCLOPS genes (for Copy number alterations Yielding Cancer Liabilities Owing to Partial losS), evoking the mythical giant that was dependent on its one eye rather than the normal complement of two.

When researchers checked to see if any of the CYCLOPS genes were neighbors of missing tumor suppressor genes, as Frei had hypothesized two decades earlier, they found that, indeed, many were.

Investigators next surveyed the CYCLOPS genes to see if they have similar or divergent functions within the cell. "We found that they're heavily involved in the components of three critical cell structures: the spliceosome, the ribosome -- which use genetic information to construct proteins for the cell -- and the proteasome, which is a vital protein machine that disposes of unneeded protein material. This suggests that they're required for cell proliferation or survival," Hahn remarks.

When the researchers ranked the 56 CYCLOPS genes by the degree to which the cancer cells were dependent on them, the gene that topped the list was PSMC2. When they administered a PSMC2-blocking agent to mice whose tumors lacked a copy of the PSMC2 gene, the tumors shrank dramatically. "It was a powerful demonstration of the potential of CYCLOPS genes to serve as targets for cancer therapies," Beroukhim explains.

The fact that CYCLOPS genes are often neighbors of tumor suppressor genes makes them even more attractive as drug targets, the study authors say. Tumor suppressor genes themselves have proven exceedingly difficult to target. In cancers with missing copies of tumor suppressor genes, blocking nearby CYCLOPS genes offers a promising way to dampen cell proliferation.

"This study represents a bringing-together of two approaches to understanding the basic mechanics of cancer," Hahn states. "One involves research into the effect of gene copy number changes on cancer. The other is a systematic exploration of the function of individual genes.

"By combining these approaches, we've been able to identify a distinct class of cancer-cell vulnerabilities associated with the copy number loss of essential genes."

The study was funded in part by the National Institutes of Health and the National Cancer Institute (RC2 CA148268, U54 CA143798, K08 CA122833, T32 GM008313, RO1 GM051923-17, and U54 CA112962), the H.L. Snyder Medical Foundation, the V Foundation, a Conquer Cancer Foundation Young Investigator Award, and Sass Foundation Fellowship.

The lead authors of the study are Deepak Nijhawan, MD, PhD, and Travis Zack, of Dana-Farber and the Broad Institute. Co-authors are Matthew Strickland, Rebecca Lamothe, and Shyemaa Shehata of Dana-Farber; Steven Schumacher and Joseph Rosenbluh, PhD, of Dana-Farber and the Broad; Aviad Tsherniak, Glenn Cowley, PhD, Barbara Weir, PhD, Jill Mesirov, PhD, and David Root, PhD, of the Broad; Yin Ren PhD of the Harvard-MIT Division of Health Sciences and Technology; Henrike Besche, PhD, and Alfred Goldberg, PhD, of Harvard Medical School; and Sangeeta Bhatia, MD, PhD, of the Broad and the Harvard-MIT Division of Health Sciences and Technology.

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Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/ntQcXLIt4ao/120815131139.htm

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Pool Builders Magnolia TX - ?Aqua Scapes pools and spas?: One ...

If you are looking for spa service providers, then your search ends at Pool Builders the Woodlands TX. You can have standalone spa or spa associated with pool. We will build the one you want in your premise.

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Tweet This Pool or spas adds elegance and charm to your living premise. Moreover, getting pool or waterfall build up in your campus will enhance the utility of the waste yard. If you are in search of any credible swimming pool constructor, then your hunt ends at "Aqua Scapes polls and spas".

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Health Fitness ? Health, Fitness & Weight Loss ? A Great Theme For ...

It appears like all people is into overall health and physical fitness these days. Paid advertising packages on television present beautiful people who you should not look like they need to physical exercise, operating out and consuming wholesome, presumably to tell the rest of us that we can seem and come to feel like them. There is certainly nothing at all incorrect with that. Contemporary society requirements fitness part designs so that others can design themselves after them. The fact is, nonetheless, that the vast majority of individuals you should not go to the gym or consume effectively well balanced foods.

Portion of the dilemma is since people are just so active. The other component is that a lot of merely you should not have the want or the power to acquire care of on their own the way that they ought to. This is ever the a lot more explanation to significantly think about starting up a company that focuses on people?s overall health. Men and women want to know that there are merchandise now on the market that can give their bodies several of the nutritional vitamins and minerals that their diets absence. For these of you who are considering about commencing a organization and producing money, the health, nourishment and weight reduction subject is one that can give you the industry market to considerably adjust your economic outlook and to help alter people?s lives for the better.

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Why Diets Don?t Work ? Health Fitness


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Yoga, Yoga Weight Loss System

Yes You Can! Lose Weight With Yoga. Designed By Charry Morris, The Yoga Instructor To The United States Ski Team, The Yoga Weight Loss System Will Help You Reach Your Weight Loss Goals Using Yoga As Your Guide.

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